Journal article
Regulation of Janus kinases by SOCS proteins
NJ Kershaw, JM Murphy, IS Lucet, NA Nicola, JJ Babon
Biochemical Society Transactions | Published : 2013
DOI: 10.1042/BST20130077
Abstract
JAKs (Janus kinases) are essential mediators of almost all biological signalling events initiated by haemopoietic and immune cytokines. However, aberrant and/or prolonged JAK-induced signalling is detrimental and can give rise to a number of inflammatory and proliferative pathologies. For this reason, the tyrosine kinase activity of the JAKs is carefully regulated at a number of different levels. Primarily, this is achieved by: (i) ensuring that the catalytic domain is 'switched off' under basal conditions, and (ii) inhibiting the activity of JAK after it has been switched on. Whereas the first mode of inhibition is mediated by JAK's own pseudokinase domain as well as the action of phosphata..
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Awarded by National Cancer Institute
Funding Acknowledgements
The original research described in the present review was supported by the National Health and Medical Research Council of Australia [programme grant numbers 461219 and 487922, and project grant number 1011804], the U.S. National Institutes of Health [grant number CA22556], the Victorian State Government Operational Infrastructure Support Grant, and the National Health and Medical Research Council Independent Research Institutes Infrastructure Support Scheme [grant number 361646]. N.A.N. acknowledges fellowship support from the National Health and Medical Research Council, J.M.M and J.J.B. from acknowledge fellowship support from the Australian Research Council.